How many injections of XiaFlex do I need?
How is Xiaflex for Peyronie’s disease treatment administered?
Xiaflex is administered intra-lesionally, meaning it is injected into the Peyronie’s plaque. Penile remodeling or modeling has also been used in addition to collagenase injections to achieve improvement in outcomes.
In the studies that showed the beneficial effects of intralesional injection of collagenase into the penile plaque, injections were performed twice weekly. IMPRESS (Investigation for Maximal Peyronie’s Reduction Efficacy and Safety Studies) followed % change in penile curvature and change in the Peyronie’s disease questionnaire symptom bother score at 1 year (52 weeks). Patient received two injections per week for 4 weeks, repeated every 6 weeks for 4 treatment cycles.
What is Penile Remodeling?
Penile Remodeling refers to manual manipulation of the penis in an effort to mechanically change the penile plaque and to straighten out the curvature.