Treatment of Pain in the Penis due to Peyronie’s Disease

Pain in the penis especially that occurs during erection in men with Peyronie’s disease often brings men to the urologist.  Penile pain during erection may be challenging to treat.  A number of commonly used medications and treatment approaches are available.

Given the best available evidence from randomized controlled studies, we favor a multimodal approach to treatment of penile pain in men with Peyronie’s disease.   Oral medications including pentoxifylline are beneficial for penile pain as well as penile curvature.  Penile remodeling either manually or with a with penile traction device appears to be beneficial in terms of curvature resolution as well as improvement in penile pain.

For men with erectile dysfunction the use of PDE5 inhibitors (Viagra, Cialis, etc) appears to benefit both ED and penile pain possibly through improved oxygenation.  Finally intralesional injections with verapamil can be beneficial.



Last modified on April 6, 2014