What is Peyronie’s Disease?


Peyronie’s disease refers to a penile curvature or bent penis.  It is often associated with a palpable bump or ‘plaque’ on the shaft of the penis.  Depending on the severity of the curve, the condition can be minor or severely limiting.

What is Peyronie’s Disease?

Peyronie’s disease refers to penile curvature or bend.  There is often as associated nodule or ‘plaque”.  It is thought that the plaque is caused by abnormal deposition of collagen and calcifications in response to microtrauma in the shaft of the penis.  The penile plaque often feels like a hard nodule in the penile shaft.   The curvature can be associated with pain in particular during erection and during sexual intercourse.  The penile curvature/plaque can also make the intercourse painful for the partner.  If the curvature is severe enough it may make it difficult or impossible to have intercourse.  The pain in the penis and discomfort can be experienced by the patient; the partner can experience discomfort and pain from the abnormal angulation. Plaques can be circumferential and cause a “neck’ effect of the penis with a narrowing of the penis along the length of the shaft.

Peyronie’s disease is associated with significant psychological distress for the patients and their sexual partners.

While are no FDA approved pharmaceutical therapies for Peyronies disease, an approval for collagenase injectsion based on randomized controlled studies is expected in December 2013.  A number of less effective treatments is used by physicians to treat patients with Peyronie’s disease.


Last modified on September 2, 2013